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| |
FISH (n = 41)
|
IHC (n = 39)
|
|---|
|
Homo
|
Hemi
|
Intact
|
P
|
Loss
|
Intact
|
P
|
|---|
|
Age
|
62
|
66
|
62
|
0.50
|
62
|
62.5
|
0.77
|
|
Time to Biochemical Recurrencea
|
45
|
87
|
83.5
|
0.37
|
82
|
84
|
0.52
|
|
Preoperative PSA
|
15.5
|
12.4
|
7.08
|
0.47
|
10.9
|
7.57
|
0.46
|
|
Gleason Score
|
|
3 + 4
|
2
|
1
|
30
|
0.001*
|
5
|
28
|
0.29
|
|
4 + 3
|
1
|
4
|
3
|
2
|
4
|
|
Pathological Stage
|
|
2
|
1
|
5
|
27
|
0.09
|
4
|
28
|
0.08
|
|
3
|
2
|
0
|
6
|
3
|
4
|
|
Positive Surgical Margins
|
|
No
|
0
|
4
|
23
|
0.04*
|
3
|
22
|
0.66
|
|
Yes
|
3
|
1
|
10
|
4
|
10
|
|
Perineural Invasion
|
|
No
|
2
|
1
|
12
|
0.42
|
5
|
10
|
0.08
|
|
Yes
|
1
|
4
|
21
|
2
|
22
|
|
Extraprostatic Extension
|
|
No
|
1
|
5
|
27
|
0.09
|
4
|
28
|
0.08
|
|
Yes
|
2
|
0
|
6
|
3
|
4
|
|
Vesicle Invasion
|
|
No
|
2
|
5
|
30
|
0.32
|
6
|
30
|
0.45
|
|
Yes
|
1
|
0
|
3
|
1
|
2
|
|
Biochemical Recurrencea
|
|
No
|
2
|
4
|
25
|
0.76
|
5
|
26
|
0.24
|
|
Yes
|
1
|
1
|
5
|
2
|
3
|
|
Gleason Score Upgrade
|
|
No
|
1
|
2
|
15
|
0.02*
|
2
|
16
|
0.40
|
|
3 + 4
|
1
|
0
|
15
|
3
|
12
|
|
4 + 3
|
1
|
3
|
3
|
2
|
4
|
- Median per group for time to biochemical recurrence is shown in months. Median of preoperative PSA levels are shown in ng/mL. Median of age at surgery is indicated in years. Kruskal-Wallis test was used to compare continuous variables for FISH data and Mann-Whitney test for IHC data. Categorical variables were compared through Fisher’s exact test. *P < 0.05. aData available for 40 patients. FISH fluorescence in situ hybridization, IHC immunohistochemistry, Homo Homozygous deletion, Hemi Hemizygous deletion
